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Newer IBS Medications

There are newer medications that have been shown to be effective in treating multiple symptoms of irritable bowel syndrome (IBS) in multi-center, high quality clinical trials. These are prescription medications intended for specific use under a doctor’s supervision.

Alosetron (Lotronex) blocks serotonin signals that transmit sensory information (painful and nonpainful) from the gut to the brain and helps to reduce diarrhea and belly pain. Alosetron has been approved for the use in women with severe diarrhea-predominant IBS (IBS-D). It is only prescribed under restricted use due to rare but potentially serious side effects.

Lubiprostone (Amitiza) helps to promote secretion through chloride channels in the bowel which in turn promote peristalsis, the coordinated muscle contractions that propel contents through the gastrointestinal (GI) tract. This medication has been shown to be effective for treating constipation symptoms. It is approved for use in women with constipation-predominant IBS (IBS-C), and in men and women with chronic constipation (without predominant abdominal pain).

Linaclotide (Linzess) is in a class of medications called guanylate cyclase-C agonists. It works by increasing the movement of contents through the GI tract and by blocking pain signals in the intestines. The medication is prescribed in adults aged 18 and older for IBS with constipation (IBS-C) and for chronic constipation (CC). In studies, patients taking linaclotide experienced improvement in multiple symptoms including pain or discomfort, bloating, and bowel function. Linaclotide is available in Europe for the treatment of IBS with constipation (IBS-C) under the brand name Constella.

Medications Being Tested 

There is a potential role of some bacteria residing in the gut to be associated with IBS symptoms in some people. Recent studies have shown that antibiotics, which reduce or alter the bacteria in the gut, may relieve some symptoms of IBS.

Xifaxan (Rifaximin) is one antibiotic, currently under investigation (not yet approved by the U.S. Food and Drug Administration) for treatment of IBS. In studies it has been found to improve IBS symptoms of bloating and diarrhea after a 10–14 day course of treatment. It is only slightly absorbed in the gut and is generally tolerated well. Although some patients may experience relief of IBS symptoms for up to 2–3 months after taking rifaximin, more information is needed about the duration of symptom relief and the best management approach to prevent recurrence of symptoms or if symptoms recur.


Antidepressant MedicationsProbiotics and Antibiotics


Adapted IFFGD Publication #101 revised and updated by Douglas A. Drossman, MD, Drossman Gastroenterology PLLC, Chapel Hill, NC and IFFGD Publication #168 by Tony Lembo, MD and Rebecca Rink, MS, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA.

Last modified on September 15, 2014 at 01:17:26 PM